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doi: 10.1016/j.biopha.2022.112643 41

The conservative reasoning researchers describe generally includes: Titrate one variable at a time

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[2] Irritants include poorly fitting dentures, licking the lips or drooling, mouth breathing resulting in a dry mouth, sun exposure, overclosure of the mouth, smoking, and minor trauma

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Doxorubicin has been reported to induce significant senescence in breast cancer cell lines, particularly promoting SA--gal expression in MCF7 cells line indicating a substantial impact of p53 on senescence induction [58]