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MC1R is a G-protein-coupled receptor (GPCR) that, upon agonist engagement, activates the Gs/adenylate cyclase pathway, increasing intracellular cAMP and activating PKA-linked signalling cascades that upregulate tyrosinase activity and drive eumelanin synthesis the dark, UV-protective form of melanin

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doi: 10.3390/medicina57070714 32 KesslerRCChiuWTDemlerOMerikangasKRWaltersEE