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Murine macrophage RAW264.7 and human monocyte U937 cells were treated with BBR and heat killed S

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During the reduction of peroxidase by mammalian GPX1, the Sec active site needs to be modified to form an intermediate stable form (Figure 1)

While the mechanisms are not known, these finding are consistent with previous in vitro studies of GSH on lymphocyte proliferation and NK cell activity 4043