The GLP-1R is a G-protein coupled receptor that has wide tissue expression, including in the brain, the wall of the portal vein near the hilus of the liver, and arteries and arterioles from various organs (kidney, heart, pancreas, and intestine) [18]
On the tongue tip, an estimated ;19% of Americans report changes in their sense of taste as they get older, which could be cause for alarm, as research suggests that loss of taste could be a signal of neurodegenerative diseases such as Alzheimers, as well as cardiovascular ones like heart failure and stroke
It also reduces both the production and effectiveness of GLP-1
Educating patients about what to expect can improve adherence and outcomes
as well
92% of patients achieved more than 10% weight loss compared to 10% on diet and exercise counselling alone