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Insufficient intake of magnesium, loss of magnesium through the digestive system and kidneys, and redistribution of magnesium from the extracellular space to the intracellular space are the main causes of magnesium deficiency (182)

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In streptozotocin-induced diabetic mice, insulin increases expressions of tight junction proteins in cerebral microvessel, including occludin, claudin-5, and zonula occludens-1 [108]

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"Could it Be B12?: An Epidemic of Misdiagnoses" by Sally Pacholok and JJ

Furthermore, B12 deficiency is associated with elevated homocysteine levels, which have been implicated in various inflammatory processes