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Oral supplementation, particularly in a liposomal format, is generally considered more effective for systemic antioxidant support because it addresses the internal cause of oxidative stress

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimers diseases

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Similarly, reduced KYN/TRP ratios, lower IDO and TDO mRNA expression, and decreased QA levels changes that correlate with reduced TNF- and IFN- were observed in the ventrolateral prefrontal cortex of individuals with MDD [64]

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