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The study of the pharmacokinetics of digoxin in healthy volunteers showed that, after oral administration or intravenous injection of 0.6 and 1.2 mg of digoxin (from 0.0089 mg/kg to 0.0179 mg/kg, mean weight of patients 67 kg), maximal mean concentrations of these CTSs in plasma were 4.3 and 9.5 ng/mL (5.5 nM and 12 nM correspondingly) observed in 40 min (Hinderling and Hartmann, 1991)
O., Omoniyi I
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GST is polymorphic and three polymorphisms decrease or abolish GST activity, although it is unclear whether possession of these polymorphisms leads to an increased propensity for paracetamol toxicity [41]
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