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In combination with immunological cross-reactivities and functional data they formed the basis of an evolutionary tree (Figure 1 shows a phylogram based on the aminoacid sequences of the 18 distinct gene products occurring as soluble dimeric proteins in humans

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Metabolite-metabolite and metabolite-gene interaction analysis To further explore the functional relationships among metabolites and their potential links to gene regulation, metabolitemetabolite and metabolitegene interaction networks were constructed using plasma metabolomic data from ASD and healthy control participants (Fig

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