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What Real Long-Term Users Are Actually Doing I interviewed 47 patients who have used GLP-1 or GIP/GLP-1 agonists for 18+ months

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The specific effects on the development of RA by DPP4 enzymatic inhibition will need to be studied in future randomized controlled studies

Physiological Reviews, 1998

Some patients experience increased bowel frequency or looser stools, particularly during the initial weeks of treatment or after dose escalation

Anyone with a personal or family history of medullary thyroid carcinoma or MEN 2 (a boxed-warning contraindication), a history of pancreatitis, or serious hypersensitivity to semaglutide