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doi: 10.1016/j.celrep.2016.03.091 119 ToninGErenSMlinariZDubravkaJErenHorvatSet al

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PMID: 25826322

40 These findings present intriguing possibilities for potential treatments and further research in the fields of immunology and infectious diseases

That short duration is precisely the limitation that later motivated the development of stabilized and PEGylated GHRH successors

La hiptesis tri-agonista parte del trabajo seminal de Matthias Tschp y Richard DiMarchi en el Helmholtz Zentrum Mnchen y la Universidad de Indiana a principios de la dcada de 2010, que demostr en modelos animales que la coactivacin racional GLP-1 + GIP + glucagn superaba a cualquier mono-agonista en prdida ponderal sin descompensar glucemia