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Endothelial cells (ECs) covering the inner surface of the vascular wall can generate, activate, and release various vasoactive substances and regulate cardiovascular function, including nitric oxide (NO), prostacyclin (PGI2), endothelin-1 (ET-1), and endothelium-derived contracting factors (EDCF)

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A combinatorial intervention targeting multiple nodes can synergistically overcome the death-resistance barrier of leukemia cells, offering a multidimensional approach to address therapeutic challenges posed by AML clonal evolution and microenvironmental sheltering

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This is also a great shot for increased energy