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Subjects were treated once daily at night for 8 weeks with Tri-Luma Cream (hydroquinone [HQ, 4%] + tretinoin [RA, 0.05%] + fluocinolone acetonide [FA, 0.01%]) or 1 of 3 possible combinations of 2 of the 3 active ingredients contained in the same vehicle: RA 0.05% + HQ 4%, HQ 4% + FA 0.01%, or RA 0.05% + FA 0.01%

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