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SSRIs and other antidepressants increase BDNF over time, so combining them with exogenous BDNF modulators could theoretically produce additive or unpredictable effects
Researchers commonly hold a step longer if GI side effects are not tolerated rather than skip ahead
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11.8% average weight loss as monotherapy in Phase 3 trialsclinically significant and comparable to first-generation GLP-1 medications
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