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10.1126/science.1091230 Science 113 MaillouxR

55 used a classical NKG2D CAR-T in different models of senescence to illustrate the specificity of this approach as senolytic approach

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This peptide has shown excellent safety profiles in animal studies with no lethal dose identified, though human clinical trial data remains limited

doi: 10.3389/fendo.2018.00725 Received 17 August 2018 Accepted 15 November 2018 Published 29 November 2018 Volume 9 - 2018 Edited by Richard Ivell, University of Nottingham, United Kingdom Reviewed by Giuliano Marchetti Bedoschi, Universidade de So Paulo, Brazil

MDHA that is not rapidly reduced can dismutate to ascorbate and DHA, which can then be reduced by GSH with the concomitant production of GSSG (Figure 1)