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And in states like California, there have been multiple instances in which independent medical reviews overturned health insurer obesity medication denials

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GLP-1 directly activates anorexigenic POMC and CART neurons and indirectly inhibits, via GABAergic transmission, orexigenic NPY and AgRP neurons [39]

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What is GLP-1 and why is it important

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Others note the potential for retatrutide, if cleared, to make its way onto obesity treatment guidelines, particularly if studies identify comparable or higher effects

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It balances clinical evidence with financial reality and gives employers a documented, defensible policy

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