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Activation of the GLP-1R by GLP-1 also results in recruitment of -arrestin-1 (Arr1) and -arrestin-2 (Arr2), which mediate receptor internalization and may serve as scaffolds for G protein-independent signaling ( 18, 19 )
MetS, a condition that encompasses several factors such as central obesity, diabetes, hypertension, and dyslipidemia 10 , also poses a high risk of developing cardiovascular diseases or stroke 6 , and increases the risk of mortality 11
And I think this really speaks to the issue of obesity stigma, doesnt it
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One of the therapeutic modalities used here include Cognitive Behavioral Therapy (CBT) in the course of individual and and group counseling