(DHFR = dihydrofolate reductase
Liver slices from mice exhibited marked liver injury when incubated with acetaminophen, which was accompanied by extensive metabolism of the drug and by glutathione conjugate formation (demonstrating that metabolic bioactivation had occurred), while mouse liver slices that were incubated with equivalent doses of AMAP exhibited a markedly reduced extent of injury and did not generate detectable levels of glutathione conjugates
Liu H, Zhang X, Vinogradskiy YY, Swisher SG , Komaki R, Chang JY
Daily glutathione use is common in clinical practice, though some providers recommend cycling (e.g., 5 days on, 2 days off) to prevent adaptation
Kidney Int 1991;39:598-601
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