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B12 also helps metabolize fat

Nausea, vomiting, diarrhea, and reduced appetite are described as dose-dependent, generally reversible pharmacological effects of GLP-1 and GIP activation rather than toxicity

It is important to note that these effects are still being researched and do not guarantee the same results for everyone

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I dont think we can conclude that with the small number of patients, and we have other evidence to suggest that the two are useful in combination. At 2 years, in the SGLT2 group, semaglutide was associated with decreased rate of declining eGFR compared with placebo whether calculated by serum creatinine or by cystatin C, with a difference of 0.75 mL/min/1.73 m2 per year (95% CI, 0.01 to 1.5)

Those with low energy or slow metabolism