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Ascorbic acid is generally nontoxic

Conclusion This study uncovers a novel hypoxia adaptation mechanism in Tibetans mediated by mitochondria-nuclear crosstalk, wherein the enhancement of BNIP3/NIX-mediated mitophagy contributes to the reduction of hypoxia-induced inflammation and improves oxygen utilization

Transient increases of IL-6, IL-2, and TNF are seen in immunomolecular markers in the blood, which enhances the immune system

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doi: 10.1021/cn200100h