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GLP-1 medications can lead to significant weight loss, especially when paired with healthy eating and regular physical activity as part of comprehensive lifestyle changes

Gradual weight reduction allows hormonal systems to adapt, while rapid loss triggers more pronounced menstrual disruptions

Bonora, C

Second Nature doesnt currently prescribe weight-loss medications for anyone with a BMI below 27

Activation of gastrointestinal ileal brake response with dietary slowly digestible carbohydrates, with no observed effect on subjective appetite, in an acute randomized, double-blind, crossover trial

"You just keep pushing yourself through it, keep progressing every single day a little bit more." She also lost weight from GLP-1s Brown said she lost about 100 lbs total from running and lifestyle changes, and another 90 lbs once she started Mounjaro in late 2022