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Both in vitro and in vivo studies demonstrate that the bacteria in the biofilms are efficiently eliminated by SeC@PA(+), indicating the effectiveness of the self-enhancing anti-biofilm strategy at high GSH levels

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OGM dissolved in artificial cerebrospinalfluid (CSF: NaCl 147 mM, KCl 2.7 mM, CaCl 1.2 mM) was infused at 10 L/min via microsyringe pump, delivering 4 nmol/kg (10 M solution adjusted for rat CSF volume ~ 25 L/100 g body weight)

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PMCID: PMC7533855