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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

During the preparation of this work, the author(s) used ChatGPT to correct the grammar, language and used Google Gemini to create Figure 1

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These receptors, such as ALX/FPR2 and ChemR23/ERV1 on astrocytes, play crucial roles in controlling astrogliosis, inhibiting inflammation, and supporting neuroprotection

In recent years, 5Amino1MQ Peptide (abbreviated as 5Amino1MQ), a highly selective smallmolecule peptide inhibitor targeting nicotinamide Nmethyltransferase (NNMT), has exhibited broad application prospects and become a research hotspot in obesity and adipose tissue research due to its unique mechanism, favorable targeting ability, and safety