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Unapproved peptides do not have established human dosing protocols, so users are essentially guessing at doses based on anecdotal reports

Some patients receive weekly infusions during an acute phase of fatigue or illness, then taper to monthly maintenance

Physiol Genomics 2002;11:31-6

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Watch for redness that starts tracking upward along the vein instead of staying near the needle site

Jastreboff AM et al., SURMOUNT-1, NEJM 2022 (NEJMoa2206038) : tirzepatide up to 15 mg, loss -22,5% at 72 weeks