Although injectable fillers are often considered the most accessible solution for volume restoration, treating large-volume deficits with fillers alone may lead to an unnatural appearance and the so-called overfilled syndrome, characterized by impaired facial expression [91]
The GSH-conjugated compounds generated are then actively pumped out of the cell by numerous members of the MRP/ABCC family, which appear to have broad and partially overlapping substrate specificity (Pompella et al., 2006)
Examples of these ingredients are arbutin and vitamin B
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