Stabilizing the glutathione cycle can disrupt the feed-forward loop linking oxidative stress, mitochondrial dysfunction, vascular impairment, and cardiometabolic disease
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In addition, patients aged 64 years old or older with rheumatoid arthritis and heart failure show an increased risk of hospitalization due to heart failure, so this medication is only recommended for patients with compensated heart failure if there are no other reasonable treatment options
Macotela, Y