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5.1 Risk of Thyroid C-cell Tumors Liraglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors (adenomas and/or carcinomas) at clinically relevant exposures in both genders of rats and mice [see Nonclinical Toxicology (13.1)]

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While some individual ingredients, such as berberine, have modest evidence of weight loss when taken orally at therapeutic doses, there is no evidence that meaningful amounts can be delivered through skin patches

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