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Both trials (study design below), each with ~1840 participants, are expected to be completed (104-week treatment, and there is a 52-week extension) this September with announcement of the results soon thereafter

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The GLP-1R and GIPR pathways both converge on beta cell function through incretin signaling, and retatrutide provides a tool to study the amplified incretin response that occurs when both receptors are activated simultaneously

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Apr 2004;24(4):312-6

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Eli Lilly is awaiting an FDA decision on a new indication for Mounjaro covering the reduction of major adverse cardiovascular events in patients with type 2 diabetes, supported by the SURPASS CVOT trial

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