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Moreover, conceivable sex differences, as well as potential sources of differential female responses, including estrous cycle, were assessed

Use cautiously in patients with peripheral vascular disease due to accumulation of acyl carnitine in plasma

Under the agreement terms, Hengrui will receive an upfront payment of $100 million and a near-term tech transfer milestone payment of $10 million, totaling $110 million, with the potential for clinical development and regulatory milestone payments of up to $200 million, sales milestone payments of up to $5.725 billion, and sales royalties ranging from low single digits to low double digits

After the FDA conducts an in-depth review of all supporting scientific evidence, it issues "no questions" letters indicating no safety concerns

doi: 10.1016/j.carres.2012.03.013 216 MedzhitovR