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20 GLP-1Rs are expressed in pancreatic -cells as well as various other tissues, including neurons in specific central brain regions, the peripheral afferent parasympathetic nervous system, atrial cardiac myocytes, pulmonary endothelial cells, kidney, and the GI tract, 14 reflecting the potential for pleiotropic physiological effects of GLP-1 beyond its insulin secretory effect

Kim SJ, Bale S, Verma P, Wan Q, Ma F, et al