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In general, the long-standing cytoprotection concept identifies innate epithelial and endothelial cell protection, which was long ago postulated in the stomach [41,42,43,44,45,46,47]
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Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities