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Scientific Communications: secondary prevention 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.02 - SECONDARY PREVENTION O - ESOC25-1876 ELEVATED ACUTE-PHASE EN-RAGE INCREASES THE RISK OF VASCULAR RECURRENCE AFTER ISCHEMIC STROKE Bjrn Granelli 1 , Annelie Angerfors 1 , Sofia Klasson 1 , Hahn Nguyen 1 , Cecilia Brnnmark 2 , Bjrn Andersson 3 , Tara Stanne, Christina Jern 1 Institute of Biomedicine, Department of Laboratory Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2 Department of Medicine, Geriatrics and Emergency Medicine, Sahlgrenska University Hospital/stra Sjukhuset, Gothenburg, Sweden, 3 Bioinformatics and Data Center, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Background and Aims: Increased circulating levels of high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) predict recurrent vascular events after ischemic stroke, but knowledge about proteins upstream in the inflammation cascade is lacking

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As shown in Figure 2 , following stimulation of GLP-1R by exenatide on microglia, the cAMP/PKA/p38/CREB signal transduction pathway is activated, promoting the expression of IL-10

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