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Alox15/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis

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Two hundred ninety-nine residues (53% of sequence) had been modeled with a single highest score template with 100% confidence

For NPCs culture generation, a heterozygous female mouse with paternally derived Ube3a deletion ( Ube3a p/m+ ) and a wild-type (WT) ( Ube3a p+/m+ ) male were bred to generate WT ( Ube3a p+/m+ ) and AS ( Ube3a p+/m ) littermates

[DOI] [Google Scholar] 34.Mahara F.A., Nuraida L., Lioe H.N., Nurjanah S

Mechanism 1: Glutathione Peroxidase (GPx) - The Thyroid's HO Scavenger The glutathione peroxidase (GPx) enzyme family - particularly GPx1, GPx3, and GPx4 - uses glutathione as its essential substrate to neutralize HO in thyroid cells