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Results vary significantly from person to person based on metabolism, lifestyle, and the level of hyperpigmentation

Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

mEPSC frequency declined even further when acivicin and MeAIB were co-administered, consistent with glutamate derived from the glutathione cycle having capacity to shape excitatory contributing to maintenance of excitatory activity neurotransmission when glutamine supply is restricted (Fig