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Altogether, the dysbalanced regulation of mitochondrial and cytosolic Ca 2+ cycling contributes to ASD pathogenesis by causing mitochondrial dysfunction, cell signaling breakdown, cytotoxicity, and oxidative stress

Khomami MB, Tehrani FR, Hashemi S, Farahmand M, Azizi F

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Additionally, angiotensin II contributes to endothelial dysfunction by inducing expression of vascular endothelial growth factor and increasing reactive oxygen species, which reduce the bioavailability of vasodilators (such as nitrous oxide) responsible for maintaining normal glomerular vascular tone [14]

Vitamin B12 shots are recommended for people who cannot absorb enough through food or oral supplements