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Tretinoin is typically recommended for those with more pronounced skin concerns and can lead to significant improvements in skin tone and texture

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Figure 1 2.2 Patients The study cohort were twenty children treated for (11 males and 9 females), median age 10.5 years, range 614 years, who were on follow-up at the Pediatric Endocrinology Clinic at HaEmek Medical Center in 20152022 and agreed to participate the study

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