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The trial did report a skin-related effect, described as cutaneous hyperesthesia and skin sensitivity, in about 7% of people on retatrutide compared with 1% on placebo, but it did not report alopecia or hair loss as a distinct side effect

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However, confirmatory data from larger phase 3 trials will be needed to substantiate the potential of muscle-preserving investigational therapies to address likely questions from regulators, for example around longer-term safety and efficacy, and variations across different sub-populations