One of the significant factors that disrupts in vitro embryo production is reactive oxygen species (ROS) that arise during early embryonic development 14,15,16,17
The gut microbiota can be therapeutically modulated through several approaches, including antibiotic therapy, probiotic supplementation, prebiotic administration, synbiotic interventions (155, 156) and FMT (157, 158)
Research indicates varying degrees of success, but PRP remains popular due to its general safety and minimal side effects (mainly soreness at the injection site)
Thermosensitive in situ hydrogels of rivastigmine-loaded lipid-based nanosystems for nose-to-brain delivery: characterisation, biocompatibility, and drug deposition studies
Additionally, both ENT1 and ENT2 are involved in the transport of antiviral nucleoside analog drugs, such as didanosine, zalcitabine, and zidovudine, as well as certain anticancer drugs like cytarabine and gemcitabine [95,96,97]
However, the combined effect of multiple BDNF-boosting compounds on total TrkB activation has not been systematically studied, so conservative dosing is advisable