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As the clinical evidence section highlighted, there are now successful examples (e.g., the QLQX heart failure trial, and growing data on berberine)

Red Flags: When to Contact Your Doctor Severe or persistent abdominal pain , especially upper abdominal pain radiating to the back this can signal pancreatitis and requires immediate evaluation

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The drugs are increasingly being used as an appetite suppressant by people looking to lose weight

Furthermore, ion concentrations in the CNS are controlled by endothelial ion transporters and channels (Nance et al., 2022)

Also diarrhoea, peripheral vascular thrombosis, transitory exanthema, or urticaria