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The cardiometabolic improvements seen during semaglutide treatment reverted towards the baseline in our study, similar to the findings in the STEP 1 study (10)

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Acute pancreatitis In January 2026, the UK MHRA has instructed manufacturers to update the product information for all GLP-1 and dual GIP/GLP-1 receptor agonists to highlight the potential risk of severe acute pancreatitis associated with these drugs, including rare reports of necrotizing and fatal pancreatitis [13]

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37 Rapamycin and other mTOR inhibitors similarly promote combined autophagy-mitophagy responses, improving mitochondrial integrity and cardiac outcomes in multiple disease models