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Retatrutide should not be used without medical supervision because it is still investigational and affects multiple metabolic pathways

Retatrutide is an investigational triple hormone receptor agonist being developed by Eli Lilly

In Phase 2, the 12 mg group lost an average of 24.2% body weight over 48 weeks

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March 13, 2025

Such a movement consequently shortened the length of -helix at ECL1 in apo state and extended TM2 by one turn, thereby stabilizing the ECD conformation via an extensive network of complimentary polar and non-polar contacts (Fig