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At week 68, there was a mean 15.4% change in body weight for semaglutide 2.4 mg vs 5.1% for placebo, and a mean 14.3 cm vs 6.0 cm change in waist circumference, respectively
Certain lifestyle choices can influence neurodegeneration: even low to moderate alcohol consumption has been found as a risk factor, and poor sleep quality is directly linked to cognitive issues, including increased risks of dementia
The mechanism is dose-dependent but not inevitable
The primary endpoint, MACE, was the time to first occurrence of a three-part composite outcome which included cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke
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