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Bioequivalence studies with pharmacokinetic endpoints for drugs submitted under an ANDA guidance for industry

Mod Pathol 28:391402 Monazzam A, Lau J, Velikyan I et al (2018) Increased expression of GLP-1R in proliferating islets of men1 mice is detectable by [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 /PET

While still highly significant versus baseline, the high-dose group actually produced fewer new hairs than the low-dose group consistent with the biphasic dose-response seen in the 2007 Pyo laboratory study where higher copper peptide concentrations inhibited rather than stimulated growth

5) potentiation of ISR

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Reduced brain serotonin transporter availability in major depression as measured by [123I]-2-carbomethoxy-3-(4-iodophenyl) tropane and single photon emission computed tomography