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Patients with a history of long-term NSAID use who have developed gastric irritation or mucosal damage that persists despite stopping the NSAIDs

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BPC-157: Maintain 250-500 mcg twice daily Cryotherapy: Reduce to 2-3 local ice applications daily Consider contrast therapy (alternating cold and heat) if swelling has decreased Begin gentle range-of-motion exercises if pain permits Shift emphasis toward tissue repair while maintaining inflammation control

doi: 10.1016/S0928-4257(97)89478-8

Days 1-3: Possible early reduction in inflammation and background pain Days 4-7: Noticeable decrease in pain intensity for many users Weeks 2-3: Improved grip strength and reduced activity-related pain Weeks 4-6: Significant functional improvement