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Results showed combination therapy achieved 83% clinical response versus 61% for golimumab monotherapy and 75% for guselkumab monotherapy, with AEs including UC flares, respiratory infections, and headache but no deaths or malignancies during the 12-week induction period, demonstrating superior efficacy of dual biologic approach over single-agent treatment ( An ongoing Phase 2b randomized, double-blind trial investigates the golimumab/guselkumab combination therapy (DUET-UC Study, NCT05242484) at various dose levels compared to placebo and individual monotherapies in 577 patients with moderately to severely active UC who failed prior advanced therapies

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J Investig Allergol Clin Immunol 27(3):175182

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