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GLP-1RAs mimic the endogenous GLP-1, which belongs to the incretin family of metabolic hormones involved in insulin production, delayed gastric emptying, and enhanced satiety

They point to the pharmacokinetic rationale, the consistent anecdotal evidence from patients, and the low theoretical risk when total weekly dose is maintained

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Cholesterol is transported throughout the body as lipid-protein complexes called lipoproteins

Mild side effects such as nausea, vomiting, diarrhea, and constipation were more frequent in the retatrutide group

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