Interestingly, high-dose melatonin (100 M alone) induced a partial suppression of SPMS expression, consistent with the hormesis model, in which moderate melatonin levels optimize polyamine gene expression, whereas excessive concentrations may inhibit this process unless counterbalanced by putrescine
10.1152/ajpendo.00237.2004
the absence of pain suggested that gall-stones were not the cause
And this was useful because you could ask, Well, why in the 70s didnt you just make this drug then if you knew about this? And the answer is that peptide chemistry wasnt very mature
The conjugation of GSH with 1-chloro,2-4 dinitrobenzene (CDNB), a hydrophilic substrate, was examined spectrophotometrically at 340 nm to measure glutathione S- transferase activity 44
Biomolecules 9 , 79 (2019)