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The preservation of the active site architecture, notably the cysteine residue at position 36 (Cys 36 ), coupled with the marked reduction in enzymatic activity exhibited by the GpoA Cys36Ala variant relative to the wild-type enzyme, provides compelling biochemical support for the essential role of this residue in mediating GpoAs peroxidase function
Among the metals for which this mechanism has been demonstrated are: zinc [157], cadmium [149,158,159], mercury [160,161], manganese [159,161,162,163], cobalt [164], nickel [165]
TY and TH are the guarantors of this work and, as such, have full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis
