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Spiegel, M
Graphical Abstract Similar content being viewed by others Abbreviations DLAT : Dihydrolipoamide S-acetyltransferase FDX1: Ferredoxin 1 GCLC: Glutamate-cysteine ligase catalytic subunit ICB: Immune checkpoint blockade ICD: Immunogenic cell death L-BSO: L-Buthionine-(S,R)-sulfoximine LIAS: Lipoic acid synthetase SLC31A1: Solute carrier family 31 TIME: Tumor immune microenvironment TNBC: Triple-negative breast cancer Funding This work was supported by the National Key Clinical Specialty Construction Program, the Science and Technology Program of Chengdu (2024-YF05-00487-SN), the Science and Technology Program of Tibet Autonomous Region (XZ202401RK0005), the Sichuan Science and Technology program (2023YFS0133), the Natural Science Foundation of Xiamen Municipality (3502Z202374035)
Trends in Peptide Drug Discovery
S = selection of patients initiating semaglutide, tirzepatide, dulaglutide, or sitagliptin (as a placebo proxy) via propensity score 1:1 nearest neighbor matching to mimic randomization
Carnitine is important to lipid metabolism in brain in general, where fatty acid oxidation is less significant though still relevant, and there is interest in its use for neuroprotection in disorders that include traumatic and other brain injuries and Alzheimer's disease
L-carnitine (LC) and quercetin (QT) are two naturally occurring compounds with well-established antioxidant and anti-inflammatory properties
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