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Following heme internalization, heme oxygenase-1 (HMOX-1) degrades heme to produce bilirubin, carbon monoxide, and ferrous ions, which inhibit the interactions of iron-binding proteins with iron response elements in FPN mRNA, thereby upregulating FPN expression and promoting tumor growth (81)

Often referred to as the "master antioxidant," glutathione helps neutralize free radicals, support detoxification pathways, and maintain healthy cellular function

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Increased adducin expression has also been implicated in cell proliferation (Bowen et al, 2003)

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