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In this study, we created a mouse model of fibrosarcoma, which has no reported relationship with ovaries, in B6 mice (M group) to identify the key NRTP-induced factor that impairs the ovaries and investigate the detailed functional mechanism involved

The inflammasome: A danger sensing complex triggering innate immunity

Concurrently, mitochondrial ROS (mtROS) amplifies vascular dysfunction by oxidizing BH4, uncoupling endothelial eNOS, and reducing NO bioavailability while also activating pro-inflammatory pathways (e.g., NLRP3 inflammasome) and stimulating NOX activity, creating continuous oxidative damage (Penna and Pagliaro, 2025)

(Weinh) 9 (11), e2103820